id: Pfam:PF06821
pfam_id: PF06821
name: Serine hydrolase
short_name: Ser_hydrolase
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06821
counters:
  proteins: 7512
  matches: 7519
  proteomes: 5469
  taxa: 8376
  structures: 5
  alphafold_models: 4651
  domain_architectures: 33
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010662
description: Members of this family have serine hydrolase activity. They contain a conserved serine hydrolase
  motif, GXSXG/A, where the serine is a putative nucleophile [[cite:PUB00070832]]. This family has an
  alpha-beta hydrolase fold [[cite:PUB00019449],[cite:PUB00049125]]. Eukaryotic members of this family
  have a conserved LXCXE motif, which binds to retinoblastomas. This motif is absent from prokaryotic
  members of this family [[cite:PUB00049125]].