id: Pfam:PF06840
pfam_id: PF06840
name: Programmed cell death protein 10, C-terminal
short_name: PDC10_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06840
counters:
  proteins: 1839
  matches: 1841
  proteomes: 1219
  taxa: 4069
  structures: 10
  alphafold_models: 1642
  domain_architectures: 22
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
description: Programmed cell death 10 protein (PDCD10/CCM3) is part of the CCM complex and is required
  for neuronal migration [[cite:PUB00076417]]. Outside of this complex, it is crucial in vascularization
  and in angiogenesis as it functions in vessel permeability and stability [[cite:PUB00096889]]. PDCD10/CCM3
  contains an N-terminal dimerisation domain and a C-terminal focal adhesion targeting-homology (FAT-H)
  domain (represented in this entry) [[cite:PUB00076418]].