id: Pfam:PF06862
pfam_id: PF06862
name: Utp25, C-terminal domain
short_name: Utp25_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06862
counters:
  proteins: 3980
  matches: 4001
  proteomes: 3238
  taxa: 8653
  structures: 0
  alphafold_models: 3382
  domain_architectures: 65
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR053939
description: UTP25 is a family of eukaryotic proteins. The family displays limited sequence similarity
  to DEAD-box RNA helicases, having alternative residues at the Walker A and DEAD-box sites, but conservation
  of structural and other key residues [[cite:PUB00109164]]. The domain is required and sufficient for
  the interaction of Utp25 with Utp3. UTP25 interacts with nucleolar protein Nop19 in S. cerevisiae, and
  Nop19p is essential for the incorporation of Utp25p into pre-ribosomes [[cite:PUB00074620]]. Proteins
  in this entry consist of two domains of which the C-terminal one is represented in this model.