id: Pfam:PF07038
pfam_id: PF07038
name: Circovirus 2, anti-apoptotic ORF4
short_name: Circovir2_Orf4
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07038
counters:
  proteins: 7
  matches: 7
  proteomes: 1
  taxa: 34
  structures: 0
  alphafold_models: 1
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009757
description: This family represents the anti-apoptotic ORF4 protein from Circovirus 2, which antagonises
  host cell apoptosis by interacting with host ferritin heavy chain (FHC). This protein physically binds
  host FHC, resulting in the reduction of FHC protein levels in host cells. The reduction of FHC concentration
  further inhibits the accumulation of reactive oxygen in host cells, leading to reduced apoptosis [[cite:PUB00097765]].