id: Pfam:PF07039
pfam_id: PF07039
name: SGF29 tudor-like domain
short_name: SGF29_Tudor
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07039
counters:
  proteins: 3982
  matches: 3994
  proteomes: 2817
  taxa: 7563
  structures: 11
  alphafold_models: 3328
  domain_architectures: 78
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010750
description: SAGA-associated factor 29 (SGF29) is involved in transcriptional regulation as a chromatin
  reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC
  or STAGA complexes [[cite:PUB00053704],[cite:PUB00088833],[cite:PUB00099984],[cite:PUB00058697],[cite:PUB00099985]].
  It specifically recognises and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for
  the trimethylated form (H3K4me3). It also may be involved in MYC-mediated oncogenic transformation [[cite:PUB00053704]].
  This entry represents the two tandem tudor-like domains found at the C-terminal of yeast and human SGF29
  proteins and the plant homologues. Each of them has a negatively-charged pocket capable of binding H3A1
  and an aromatic cage for the recognition of H3K4me2/3 residues [[cite:PUB00099984],[cite:PUB00058697]].