id: Pfam:PF07059
pfam_id: PF07059
name: Protein ENHANCED DISEASE RESISTANCE 2, C-terminal
short_name: EDR2_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07059
counters:
  proteins: 8626
  matches: 8806
  proteomes: 529
  taxa: 1506
  structures: 0
  alphafold_models: 6913
  domain_architectures: 166
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009769
description: This family represents the C-terminus (approximately 250 residues) of protein ENHANCED DISEASE
  RESISTANCE 2 (EDR2) from plants. EDR2 is a negative regulator of the salicylic acid (SA)-mediated resistance
  to pathogens, including the biotrophic powdery mildew pathogens Golovinomyces cichoracearum and Blumeria
  graminis, and the downy mildew pathogen Hyaloperonospora parasitica, probably by limiting the initiation
  of cell death and the establishment of the hypersensitive response (HR) [[cite:PUB00078901],[cite:PUB00095635]].