id: Pfam:PF07063
pfam_id: PF07063
name: 2-oxoadipate dioxygenase/decarboxylase
short_name: HGLS
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07063
counters:
  proteins: 5110
  matches: 5475
  proteomes: 4514
  taxa: 7095
  structures: 6
  alphafold_models: 3348
  domain_architectures: 39
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009770
description: This entry represents a group of bacterial, fungal and plant sequences, including 2-oxoadipate
  dioxygenase/decarboxylase (referred to as HGLS and YdcJ) from Escherichia coli. YdcJ, which is involved
  in D-lysine metabolism, catalyses a successive decarboxylation and intramolecular hydroxylation of 2-oxoadipate
  forming 2-hydroxyglutarate in a Fe(II) and oxygen-dependent manner. Members of this protein family are
  thought to belong to the the vicinal oxygen chelate (VOC) superfamily [[cite:PUB00102155],[cite:PUB00102156]].
  The structure has been solved (PDB:3iuz, PDB:6w1g).