id: Pfam:PF07139
pfam_id: PF07139
name: Spermatogenesis-associated serine-rich protein 2-like
short_name: SPATS2-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07139
counters:
  proteins: 1891
  matches: 2097
  proteomes: 857
  taxa: 2752
  structures: 0
  alphafold_models: 1669
  domain_architectures: 10
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009816
description: This family includes spermatogenesis-associated serine-rich protein 2 (SPATS2) and SPATS2-like
  proteins from mammals. SPATS2 is involved in spermatogenesis and likely to be a cytoplasmic RNA-binding
  protein [[cite:PUB00101497],[cite:PUB00101498]]. SPATS2 is highly expressed in hepatocellular carcinoma
  (HCC) and may function as an oncogene. It constitutes a novel diagnostic prognostic marker in liver
  cancer and a potential therapeutic target for the treatment of HCC [[cite:PUB00101499]].