id: Pfam:PF07159
pfam_id: PF07159
name: CYRIA/CYRIB Rac1 binding domain
short_name: CYRIA-B_Rac1-bd
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07159
counters:
  proteins: 8041
  matches: 8217
  proteomes: 1782
  taxa: 5573
  structures: 9
  alphafold_models: 6654
  domain_architectures: 71
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009828
description: This domain has been annotated as Rac1-binding domain [[cite:PUB00093956],[cite:PUB00093955]].
  It can be found in human CYRIA/CYRIB and at the N terminus of CYFIP1/2 [[cite:PUB00093957]]. CYFIP proteins
  are known RAC1 effectors that stimulate actin polymerization [[cite:PUB00093957]]. In mice, CYRIB (also
  known as CYRI or FAM49B) negatively regulates RAC1-driven cytoskeletal remodelling and plays a role
  in restricting infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes [[cite:PUB00093957]].