id: Pfam:PF07160
pfam_id: PF07160
name: Spindle and kinetochore-associated protein 1
short_name: SKA1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07160
counters:
  proteins: 1873
  matches: 1976
  proteomes: 1423
  taxa: 4522
  structures: 4
  alphafold_models: 1644
  domain_architectures: 44
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009829
description: Spindle and kinetochore-associated protein 1 (SKA1) is a component of the SKA1 complex (consists
  of Ska1, Ska2, and Ska3/Rama1), a microtubule-binding subcomplex of the outer kinetochore that is essential
  for proper chromosome segregation [[cite:PUB00061771]]. It is required for timely anaphase onset during
  mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of
  the spindle checkpoint [[cite:PUB00061805]].