id: Pfam:PF07180
pfam_id: PF07180
name: CaiF/GrlA transcriptional regulator
short_name: CaiF_GrlA
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07180
counters:
  proteins: 166
  matches: 166
  proteomes: 128
  taxa: 215
  structures: 1
  alphafold_models: 119
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR020357
description: This is a family of transcriptional regulators. CaiF is involved in carnitine metabolism
  [[cite:PUB00077941]]. GrlA is encoded within the LEE type III secretion system in the enteropathogenic
  E. coli O157:H [[cite:PUB00076312]]. GrlR interacts with GrlA at its Helix-Turn-Helix (HTH) motif, preventing
  GrlA from binding to its target promoter DNA.