id: Pfam:PF07190
pfam_id: PF07190
name: Tumour necrosis factor receptor, SECRET domain
short_name: CrmD_SECRET
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07190
counters:
  proteins: 87
  matches: 87
  proteomes: 19
  taxa: 92
  structures: 2
  alphafold_models: 51
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010806
description: This domain, named as the SECRET domain, is found at the C-terminal end of Tumour necrosis
  factor receptor (CrmD) from the orthopoxvirus Ectromelia virus. This domain binds a subset of human
  and mouse CC, CXC and C chemokines. It is thought to be responsible for the anti-chemokine activity
  of CrmD. The SECRET domain monomer adopts a beta-sandwich fold, consisting of two parallel beta-sheets
  with five and six anti-parallel strands, and the connecting loops [[cite:PUB00151577]]. This domain
  is also found in other uncharacterised sequences from poxvirus, including Protein OPG192 and Protein
  C8 from Vaccinia virus.