id: Pfam:PF07262
pfam_id: PF07262
name: CDI immunity protein
short_name: CdiI
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07262
counters:
  proteins: 357
  matches: 357
  proteomes: 236
  taxa: 552
  structures: 5
  alphafold_models: 215
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009888
description: CdiI immunity proteins function as part of the bacterial contact-dependent growth inhibition
  (CDI) system. CDI is mediated by the CdiB-CdiA two-partner secretion system. Each CdiA protein exhibits
  a distinct growth inhibition activity, which resides in the polymorphic C-terminal region (CdiA-CT).
  Cells with the CDI sytem also express a CdiI immunity protein that blocks the activity of cognate CdiA-CT,
  thereby protecting the cell from autoinhibition. In many CDI systems the cdiBAI genes are followed by
  orphan cdiA-CT/cdiI modules, suggesting that these modules are exchanged between the CDI systems of
  different bacteria [[cite:PUB00074283]].