id: Pfam:PF07326
pfam_id: PF07326
name: Regulator of chromosome segregation 1
short_name: RCS1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07326
counters:
  proteins: 1192
  matches: 1238
  proteomes: 706
  taxa: 2154
  structures: 0
  alphafold_models: 1113
  domain_architectures: 10
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009932
description: This family consists of several mammalian proteins of around 240 residues in length. Family
  members include regulator of chromosome segregation 1 (RCS1), also known as FAM64A, CATS or PIMREG (PICALM-interacting
  mitotic regulator). It is a substrate of APC/C. It may control the metaphase to anaphase transition
  [[cite:PUB00084339]]. It is also a substrate of the Kinase Interacting Stathmin (KIS). RCS1 is highly
  expressed in cancer cell lines in a cell cycle dependent manner and is induced by mitogens [[cite:PUB00084340]].