id: Pfam:PF07332
pfam_id: PF07332
name: Putative Actinobacterial Holin-X, holin superfamily III
short_name: Phage_holin_3_6
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07332
counters:
  proteins: 12683
  matches: 12685
  proteomes: 8591
  taxa: 11222
  structures: 0
  alphafold_models: 7594
  domain_architectures: 8
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009937
description: Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane
  domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that
  use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading
  enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided
  by the holin membrane lesion.