id: Pfam:PF07338
pfam_id: PF07338
name: YdgH/BhsA/McbA-like domain
short_name: YdgH_BhsA-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07338
counters:
  proteins: 4596
  matches: 5637
  proteomes: 538
  taxa: 823
  structures: 6
  alphafold_models: 2805
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR010854
description: This domain is found in several Enterobacterial proteins of around 90 residues in length,
  including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation
  and pathogenesis [[cite:PUB00097758],[cite:PUB00097759]]. BhsA (also known as ComC) reduces the permeability
  of the outer membrane to copper and may decrease biofilm formation by repressing cell-cell interaction
  and cell surface interaction [[cite:PUB00097760]]. Members of this entry have one copy of this domain
  with the exception of YdgH, which has three copies. The function of this domain is unknown, however,
  it is suggested to be directly involved in host-pathogen interaction [[cite:PUB00097759]].