id: Pfam:PF07366
pfam_id: PF07366
name: SnoaL-like polyketide cyclase
short_name: SnoaL
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07366
counters:
  proteins: 14779
  matches: 15446
  proteomes: 7283
  taxa: 11082
  structures: 19
  alphafold_models: 9298
  domain_architectures: 124
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR009959
description: This family includes SnoaL [[cite:PUB00021066]] a polyketide cyclase involved in nogalamycin
  biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted
  alpha-beta barrel fold [[cite:PUB00021066]]. Structural data together with site-directed mutagenesis
  experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing
  intramolecular aldol condensation [[cite:PUB00021066]].