id: Pfam:PF07510
pfam_id: PF07510
name: GmrSD restriction endonucleases, C-terminal domain
short_name: GmrSD_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07510
counters:
  proteins: 13168
  matches: 13171
  proteomes: 7699
  taxa: 11960
  structures: 7
  alphafold_models: 7977
  domain_architectures: 95
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR011089
description: This entry (previously known as DUF1524) represents a domain found C-terminal in the GmrSD
  family of modification-dependent restriction endonucleases including SspE proteins [[cite:PUB00155638]].
  SspE is a dual-function protein that exerts both N-terminal NTPase and C-terminal DNA nicking nuclease
  activities to defend against phage infection [[cite:PUB00155272]]. SspE has a phosphorothioate (PT)
  modification-binding preference and utilises epigenetic PT modification to accomplish self-nonself discrimination
  and to coordinate its NTPase and DNA nicking activities to fight against phages. The domain represented
  in this entry has a DNA nicking nuclease activity and belongs to HNH nuclease superfamily.