id: Pfam:PF07550
pfam_id: PF07550
name: Heme-binding protein Shr-like, Hb-interacting domain
short_name: Shr-like_HID
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07550
counters:
  proteins: 440
  matches: 929
  proteomes: 304
  taxa: 558
  structures: 4
  alphafold_models: 157
  domain_architectures: 250
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR011432
description: The Hb-interacting domain (HID) is found duplicated in Heme-binding protein Shr from Streptococcus
  pyogenes, a potentially lethal human pathogen, and in one to six copies in other uncharacterised bacterial
  proteins. Shr is a virulence factor that captures Hb and binds to the oxidized form of heme through
  an N-terminal region that contains two copies of this domain. HID shows a beta-sandwich-type fold in
  which two antiparallel beta-sheets are flanked by an alpha-helix [[cite:PUB00100888]].