id: Pfam:PF07773
pfam_id: PF07773
name: Tectonic domain of DUF1619
short_name: TCTN_DUF1619
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07773
counters:
  proteins: 3441
  matches: 6251
  proteomes: 1145
  taxa: 3864
  structures: 0
  alphafold_models: 2961
  domain_architectures: 51
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR011677
description: This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains conserved
  cysteine residues predicted to form disulfide bond. This domain is found in two tandem copies. It is
  predicted to fold into an alpha/beta structure with unique topology composed of a central mixed beta-sheet
  and alpha-helix packed on it. Although function of this domain is currently unknown, studies on TCTN2
  suggest that it is indispensable for its functions [[cite:PUB00097826],[cite:PUB00097827]]. TCTN1, TCTN2,
  and TCTN3 are members of the tectonic protein family that play crucial roles in ciliogenesis and ciliary
  function. While they share some common functions, each protein also has specific roles in the process
  of cilia formation and maintenance. These proteins interact with several other ciliopathy proteins,
  forming a complex known as the Tectonic ciliopathy complex. This complex is required for hedgehog signalling
  transduction and regulation of ciliary membrane composition [[cite:PUB00069722],[cite:PUB00160606]].