id: Pfam:PF07774
pfam_id: PF07774
name: ER membrane protein complex subunit 1, second beta-propeller
short_name: EMC1_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07774
counters:
  proteins: 4701
  matches: 4882
  proteomes: 3296
  taxa: 8699
  structures: 12
  alphafold_models: 3919
  domain_architectures: 100
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR011678
description: This is the second beta-propeller domain of ER membrane protein complex subunit 1. ER membrane
  protein complex subunit 1 is a component of the ER membrane protein complex (EMC, composed of EMC1,
  EMC2, EMC3, EMC4, EMC5 and EMC6). In Saccharomyces cerevisiae, the EMC seems to be required for efficient
  folding of proteins in the endoplasmic reticulum (ER) [[cite:PUB00061987]]. EMC1 contains two eight-bladed
  beta-propellers and stabilises the entire EMC complex, contacting six of the remaining eight subunits
  [[cite:PUB00096682]]. The beta-propellers are in the lumen and may serve as a platform for recruitment
  of co-factors at the site of nascent protein insertion [[cite:PUB00096682]].