id: Pfam:PF07786
pfam_id: PF07786
name: Heparan-alpha-glucosaminide N-acetyltransferase, catalytic
short_name: HGSNAT_cat
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07786
counters:
  proteins: 11708
  matches: 11716
  proteomes: 7510
  taxa: 13181
  structures: 12
  alphafold_models: 7893
  domain_architectures: 49
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR012429
description: This entry includes the catalytic domain of HGSNAT (Heparan-alpha-glucosaminide N-acetyltransferase).
  It contains the conserved histidine in the active site (His269), thought to hold the acetyl group during
  the transfer across the membrane and required for its enzymatic activity. HGSNAT transfers an acetyl
  group from cytoplasmically derived acetyl-CoA to terminal N-glucosamine residues of heparan sulfate
  within the lysosomes [[cite:PUB00090705]].