id: Pfam:PF07788
pfam_id: PF07788
name: PD-(D/E)XK nuclease superfamily
short_name: PDDEXK_10
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07788
counters:
  proteins: 249
  matches: 249
  proteomes: 109
  taxa: 379
  structures: 0
  alphafold_models: 211
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR012431
description: This family is found to carry modified motifs characteristic of PD-(D/E)XK endonuclease superfamily.
  These are the conserved Glu of motif I, the Asp surreounded by hydrophobics of motif II, EIKS of motif
  III, and the lysine of mmotif IV has migrated to an alpha-helix following the third core beta-strand.
  The conserved patch of positively charged lysine and arginine residues in the motif IV apha-helix might
  be involved in substrate-binding or be contributing to active site formation [[cite:PUB00044133]]. Members
  with an additional N-terminal coi9led-coil domain, are annotated as tropomyosin, coiled-coil or microtubule
  binding proteins [[cite:PUB00016549],[cite:PUB00044133]].