id: Pfam:PF07849
pfam_id: PF07849
name: Helical membrane plugin
short_name: HMP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07849
counters:
  proteins: 1961
  matches: 1961
  proteomes: 1449
  taxa: 2277
  structures: 4
  alphafold_models: 1361
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR012440
description: This entry represents the helical membrane plugin (HMP) domain found in a group of uncharacterised
  prokaryotic proteins, including the [NiFe]-hydrogenase Huc from Mycobacterium smegmatis [[cite:PUB00161758]].
  It is involved in the construction of oxidoreductases in prokaryotes, which allows quinone channelling
  between the membrane and various redox catalytic subunits [[cite:PUB00161759]]. It was previously known
  as DUF1641.