id: Pfam:PF07856
pfam_id: PF07856
name: Mediator of CRAC channel activity
short_name: Orai-1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07856
counters:
  proteins: 3588
  matches: 3642
  proteomes: 1398
  taxa: 4474
  structures: 8
  alphafold_models: 3178
  domain_architectures: 49
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR012446
description: ORAI-1 is a protein homologue of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1
  GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein
  has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved
  domain is thought to function in channel regulation. ORAI1- related proteins are required for the production
  of the calcium channel, CRAC, along with STIM1-related proteins [[cite:PUB00055566]].