id: Pfam:PF07946
pfam_id: PF07946
name: PAT complex subunit CCDC47
short_name: CCDC47
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07946
counters:
  proteins: 4200
  matches: 4288
  proteomes: 3257
  taxa: 8584
  structures: 4
  alphafold_models: 3589
  domain_architectures: 65
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR012879
description: This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic
  reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins
  insertion into membranes [[cite:PUB00097218]]. The PAT complex, formed by CCDC47 and Asterix proteins,
  acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs),
  releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane
  proteins [[cite:PUB00097218]]. CCDC47 ([swissprot:Q96A33]) is required to maintain the stability of
  Asterix [[cite:PUB00097218],[cite:PUB00097217]]. CCDC47 is associated with various membrane-associated
  processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane
  protein transport into the ER membrane and biogenesis [[cite:PUB00097241]]. It is also involved in the
  regulation of calcium ion homeostasis in the ER [[cite:PUB00097242]], being also required for proper
  protein degradation via the ERAD (ER-associated degradation) pathway [[cite:PUB00097243]].