id: Pfam:PF07970
pfam_id: PF07970
name: Endoplasmic reticulum vesicle transporter
short_name: COPIIcoated_ERV
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07970
counters:
  proteins: 12470
  matches: 12717
  proteomes: 3381
  taxa: 8945
  structures: 1
  alphafold_models: 10681
  domain_architectures: 221
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR012936
description: This family is conserved from plants and fungi to humans. Erv46 works in close conjunction
  with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi
  complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase
  II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localisation.
  All proteins identified biochemically as Erv41p-Erv46p interactors are localised to the early secretory
  pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles
  for transport to the Golgi [[cite:PUB00063190]].