id: Pfam:PF08213
pfam_id: PF08213
name: Mitochondrial mRNA-processing protein COX24, C-terminal
short_name: COX24_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08213
counters:
  proteins: 5909
  matches: 5909
  proteomes: 5491
  taxa: 10507
  structures: 142
  alphafold_models: 4194
  domain_architectures: 38
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013177
description: This domain of unknown function is found at the C terminal end of Mitochondrial small ribosomal
  subunit protein mS38, also known as Mitochondrial mRNA-processing protein COX24 in yeast which is involved
  in the splicing of the COX1 mRNA [[cite:PUB00076420]]. COX24 is a component of the mitochondrial ribosome
  (mitoribosome), responsible for the synthesis of mitochondrial genome-encoded proteins, including at
  least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes
  are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated
  into the membrane [[cite:PUB00089004],[cite:PUB00098057]]. This domain is also found in COX24 mammalian
  homologue Aurora kinase A-interacting protein [[cite:PUB00078824]]. This entry also includes uncharacterised
  proteins from bacteria.