id: Pfam:PF08214
pfam_id: PF08214
name: Histone acetyltransferase KAT11-type domain
short_name: HAT_KAT11
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08214
counters:
  proteins: 1484
  matches: 2178
  proteomes: 1444
  taxa: 3025
  structures: 19
  alphafold_models: 1224
  domain_architectures: 30
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR016849
description: This entry represents a histone acetyltransferase catalytic domain found in fungal proteins,
  including RTT109 (also known as KAT11) from budding and fission yeasts and Candida species. This domain
  catalyses the acetylation of lysine residues on histone H3, including H3K56, H3K9, H3K14, H3K23 and
  H3K27 [[cite:PUB00045009],[cite:PUB00042670]]. The domain functions within a complex with histone chaperones
  such as VPS75 that regulate substrate specificity [[cite:PUB00051225]]. Acetylation of H3K56 by this
  domain promotes nucleosome assembly, DNA repair and transcriptional regulation during S-phase [[cite:PUB00045009],[cite:PUB00042670]].
  The domain is also found in other histone acetyltransferases including p300/CBP which share a similar
  fold but differ in catalytic properties and cofactor requirements [[cite:PUB00051225]]. Members of this
  family show conservation across most eukaryotic fungi.