id: Pfam:PF08216
pfam_id: PF08216
name: Catenin-beta-like, Arm-motif containing nuclear
short_name: CTNNBL
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08216
counters:
  proteins: 4228
  matches: 4569
  proteomes: 3098
  taxa: 8317
  structures: 9
  alphafold_models: 3601
  domain_architectures: 69
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013180
description: CTNNBL is a family of eukaryotic nuclear proteins of the catenin-beta-like 1 type that contain
  an armadillo motif. A human nuclear protein with this domain ([swissprot:Q8WYA6]) is thought to have
  a role in apoptosis [[cite:PUB00017164]]. The interaction of CTNNBL1 with its known partners (the Prp19-CDC5L
  complex and AID) is mediated by recognition of NLS (nuclear localisation signal) motifs. The RNA-splicing
  factor Prp31 is also an interactor, with recognition also occurring through the NLS. CTNNBL1 uses its
  central armadillo (ARM) domain to bind NLS-containing partners [[cite:PUB00110056],[cite:PUB00110057]].