id: Pfam:PF08227
pfam_id: PF08227
name: DASH complex subunit Hsk3 like
short_name: DASH_Hsk3
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08227
counters:
  proteins: 1859
  matches: 1859
  proteomes: 1708
  taxa: 4301
  structures: 3
  alphafold_models: 1641
  domain_architectures: 20
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013183
description: The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the
  kinetochore prior to mitosis [[cite:PUB00017174]]. In Saccharomyces cerevisiae DASH forms both rings
  and spiral structures on microtubules in vitro [[cite:PUB00033281],[cite:PUB00033282]]. This family
  also includes several higher eukaryotic proteins. However, other DASH subunits do not appear to be conserved
  in higher eukaryotes.