id: Pfam:PF08351
pfam_id: PF08351
name: tRNA(Met) cytidine acetyltransferase TmcA, N-terminal
short_name: TmcA_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08351
counters:
  proteins: 6077
  matches: 6079
  proteomes: 5151
  taxa: 11311
  structures: 36
  alphafold_models: 4736
  domain_architectures: 102
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013562
description: This domain of unknown function is often found at the N-terminal of the bacterial tRNA(Met)
  cytidine acetyltransferase TmcA. TmcA catalyses the formation of N(4)-acetylcytidine (ac4C) at the wobble
  position of tRNA(Met) by using acetyl-CoA as an acetyl donor and either ATP or GTP [[cite:PUB00050413],[cite:PUB00056806],[cite:PUB00107449]].
  This modification is thought to ensure precise recognition of the AUG codon by strengthening C-G base-pair
  interaction and also prevent misrecognition of the near cognate AUA codon [[cite:PUB00050413]]. This
  domain is also found in mammalian N-acetyltransferase 10 (NAT10) and fungal protein Kre33. Kre33 and
  NAT10 are RNA cytosine acetyltransferases with specificity toward both 18S rRNA and tRNAs and contain
  additional putative nuclear and nucleolar localisation signals (NLS and NoLS respectively) [[cite:PUB00076725],[cite:PUB00076726],[cite:PUB00107449]].