id: Pfam:PF08354
pfam_id: PF08354
name: Fatty acid synthase subunit beta/Fas1-like, helical
short_name: Fas1-AflB-like_hel
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08354
counters:
  proteins: 3260
  matches: 3333
  proteomes: 2302
  taxa: 4165
  structures: 45
  alphafold_models: 205
  domain_architectures: 233
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013565
description: This domain has been identified in fungi and bacteria. It is found in fatty acid synthase
  beta subunit from fungi, including Fas1 from yeasts and aflB from Aspergillus parasiticus. This is an
  inserted helical domain, whose function is not clear, and is found together with the MaoC-like domain
  ([pfam:PF01575]) and the acyltransferase domain ([pfam:PF00698]) [[cite:PUB00016843]]. Fas1 is a fatty
  acid synthetase that catalyses the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA
  and NADPH [[cite:PUB00006544]]. AflB is part of the gene cluster that mediates the biosynthesis of aflatoxins
  [[cite:PUB00083132]].