id: Pfam:PF08409
pfam_id: PF08409
name: Protein O-mannosyl-transferase TMTC, DUF1736
short_name: TMTC_DUF1736
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08409
counters:
  proteins: 6936
  matches: 6939
  proteomes: 1367
  taxa: 4389
  structures: 0
  alphafold_models: 6079
  domain_architectures: 1307
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013618
description: This domain of unknown function is found in O-mannosyl -transferases TMTC1-4, and constitutes
  a loop between TM7 and TM8 located in the ER lumen that contains a small hydrophobic, but not membrane-embedded
  helix. This loop is critical for catalysis and binding of ligands, especially the lipid-linked sugar
  moiety [[cite:PUB00098068]]. TMTCs transfers mannosyl residues to the hydroxyl group of serine or threonine
  residues. The 4 members of the TMTC family are O-mannosyl-transferases acting primarily on the cadherin
  superfamily; each member has distinct roles in decorating the cadherin domains with O-linked mannose
  glycans at specific regions. These proteins also act as O-mannosyl-transferase on other proteins such
  as PDIA3 [[cite:PUB00098069]].