id: Pfam:PF08424
pfam_id: PF08424
name: NRDE-2, necessary for RNA interference
short_name: NRDE-2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08424
counters:
  proteins: 3235
  matches: 3289
  proteomes: 2637
  taxa: 7112
  structures: 0
  alphafold_models: 2523
  domain_architectures: 63
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013633
description: This is a family of eukaryotic proteins. Eukaryotic cells express a wide variety of endogenous
  small regulatory RNAs that regulate heterochromatin formation, developmental timing, defence against
  parasitic nucleic acids, and genome rearrangement. Many small regulatory RNAs are thought to function
  in nuclei, and in plants and fungi small interfering (si)RNAs associate with nascent transcripts and
  direct chromatin and/or DNA modifications. This family protein, NRDE-2, is required for small interfering
  (si)RNA-mediated silencing in nuclei. NRDE-2 associates with the Argonaute protein NRDE-3 within nuclei
  and is recruited by NRDE-3/siRNA complexes to nascent transcripts that have been targeted by RNA interference,
  RNAi, the process whereby double-stranded RNA (dsRNA) directs the sequence-specific degradation of mRNA
  [[cite:PUB00057435]].