id: Pfam:PF08489
pfam_id: PF08489
name: TiaS FLD domain
short_name: TiaS_FLD
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08489
counters:
  proteins: 592
  matches: 593
  proteomes: 586
  taxa: 1064
  structures: 7
  alphafold_models: 557
  domain_architectures: 11
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013696
description: This is the FLD domain found in tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS. TiaS is an
  archaeal ATP-dependent agmatine transferase that catalyses the formation of 2-agmatinylcytidine (agm2C)
  at the wobble position (C34) of tRNA(Ile2) [[cite:PUB00056803],[cite:PUB00154283],[cite:PUB00106019]].
  This modified base specifically recognises AUA codons. TiaS consists of four domains, the TCKD domain
  ([pfam:PF22641]) at the N-terminal followed by the FLD domain, an OB fold domain and a zinc ribbon domain
  (ZRD) domain at the C-terminal [[cite:PUB00154283]]. This domain is responsible for agmantine binding
  [[cite:PUB00056803]].