id: Pfam:PF08495
pfam_id: PF08495
name: FIST N domain
short_name: FIST
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08495
counters:
  proteins: 6777
  matches: 6781
  proteomes: 5036
  taxa: 8763
  structures: 0
  alphafold_models: 4552
  domain_architectures: 104
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013702
description: The FIST N domain is a novel sensory domain, which is present in signal transduction proteins
  from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for
  proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands,
  such as amino acids [[cite:PUB00044261]].