id: Pfam:PF08508
pfam_id: PF08508
name: Fungal domain of unknown function (DUF1746)
short_name: DUF1746
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08508
counters:
  proteins: 1326
  matches: 1353
  proteomes: 1282
  taxa: 2736
  structures: 0
  alphafold_models: 1116
  domain_architectures: 20
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013715
description: This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin
  ligase complex subunit 4 (Dsc4) from S. pombe, a component of the DSC E3 ubiquitin ligase complex required
  for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor
  from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the
  multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein
  degradation [[cite:PUB00075404]]. This domain is also found in GLD1 from S. cerevisiae, also a component
  of the DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus
  and endosome membranes via the AP3 pathway to ubiquitinate Golgi/endosome membrane proteins [[cite:PUB00098082]].