id: Pfam:PF08512
pfam_id: PF08512
name: Histone chaperone Rttp106-like, middle domain
short_name: Rttp106-like_middle
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08512
counters:
  proteins: 10226
  matches: 10251
  proteomes: 3420
  taxa: 9039
  structures: 36
  alphafold_models: 8633
  domain_architectures: 244
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013719
description: This Pleckstrin homology (PH) domain is found in the middle region of Rttp106, a histone
  chaperone involved in heterochromatin-mediated silencing [[cite:PUB00033392]]. It is also found in the
  final part of the middle domain of various FACT (facilitates chromatin transactions) complex subunits,
  such as Spt16 and either Pob3 (yeast) or the related SSRP1 (higher eukaryotes). This domain plays a
  role in DNA binding [[cite:PUB00101033],[cite:PUB00101035],[cite:PUB00101032]].