id: Pfam:PF08549
pfam_id: PF08549
name: SWI/SNF and RSC complexes subunit Ssr4 N-terminal
short_name: SWI-SNF_Ssr4_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08549
counters:
  proteins: 1093
  matches: 1098
  proteomes: 1066
  taxa: 2251
  structures: 3
  alphafold_models: 907
  domain_architectures: 18
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013859
description: This entry represents the N-terminal domain of SWI/SNF and RSC complexes subunit Ssr4 from
  S. pombe, a essential member of the chromatin structure remodelling complex (RSC) and the SWI/SNF complex
  [[cite:PUB00066307],[cite:PUB00101211]]. The structure of this domain revealed that it has a novel fold
  comprising an antiparallel beta-sheet of seven strands with alpha-helices on one side and random coil
  on the other [[cite:PUB00101211]]. It contains the highly conserved motif WxxxxxPxxGxxxxxxxxxxxxxxxDG.
  RSC is involved in transcription regulation and nucleosome positioning which controls, particularly,
  membrane and organelle development genes. The ATP-dependent chromatin remodelling complex SWI/SNF is
  required for the positive and negative regulation of gene expression of a large number of genes through
  the regulation of nucleosome remodelling [[cite:PUB00066307]].