id: Pfam:PF08568
pfam_id: PF08568
name: Uncharacterised protein family, YAP/Alf4/glomulin
short_name: Kinetochor_Ybp2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08568
counters:
  proteins: 3520
  matches: 4201
  proteomes: 2663
  taxa: 7140
  structures: 1
  alphafold_models: 2972
  domain_architectures: 43
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013877
description: This entry contains a number of protein families with apparently unrelated functions. These
  include the YAP binding proteins of yeasts. These are stress response and redox homeostasis proteins,
  induced by hydrogen peroxide or induced in response to alkylating agent methyl methanesulphonate (MMS)
  [[cite:PUB00053725]] [[cite:PUB00053726]]. The family includes Aberrant root formation protein 4 (Alf4)
  of Arabidopsis thaliana (Mouse-ear cress), which is required for the initiation of lateral roots independent
  from auxin signalling. It may also function in maintaining the pericycle in the mitotically competent
  state needed for lateral root formation [[cite:PUB00053727]]. The family includes glomulin (FAP68),
  which is essential for normal development of the vasculature and may represent a naturally occurring
  ligand of the immunophilins FKBP59 and FKBP12 [[cite:PUB00044263]] [[cite:PUB00053728]].