id: Pfam:PF08588
pfam_id: PF08588
name: Domain of unknown function at the cortex 1 (Duc1)
short_name: Duc1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08588
counters:
  proteins: 2341
  matches: 2488
  proteomes: 1476
  taxa: 3195
  structures: 0
  alphafold_models: 1913
  domain_architectures: 67
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013897
description: This entry represents the Duc1 (Domain of Unknown Function at the Cortex 1) protein, which
  is involved in maintaining proper plasma membrane lipid composition and cytokinetic ring anchoring in
  Schizosaccharomyces pombe [[cite:PUB00155608]]. Duc1 localizes to the plasma membrane, except at the
  cell division site, and its localization is controlled by interactions with the ER-PM contact site proteins
  Scs2 and Scs22 through a FFAT-like motif. Duc1 promotes proper localization of the PI-5 kinase Its3,
  thereby maintaining appropriate levels of PI(4,5)P2 at the plasma membrane. This function is important
  for proper anchoring of the cytokinetic ring during cell division. Duc1 contains a conserved domain
  previously known as the DUF1769 domain of unknown function.