id: Pfam:PF08593
pfam_id: PF08593
name: Mug135-like, C-terminal domain
short_name: Mug135_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08593
counters:
  proteins: 570
  matches: 572
  proteomes: 181
  taxa: 487
  structures: 2
  alphafold_models: 472
  domain_architectures: 13
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR013902
description: This entry represents the C-terminal domain found in Meiotically up-regulated gene 135 protein
  from Schizosaccharomyces pombe (Mug135, also known as Tdk1, O74876) and similar fungal proteins that
  are annotated as meiotically up-regulated gene products. Mug135 is a killer meiotic driver (KMD), a
  selfish genetic element that by selectively kills meiotic products lacking its gene, thereby promoting
  its own propagation. This protein exists in a nontoxic tetrameric form during vegetative growth and
  meiosis but transforms into a distinct toxic form in spores [[cite:PUB00159004],[cite:PUB00159007]].
  These proteins generally contain a long coiled-coil region with this domain found at the C-terminus.