id: Pfam:PF08683
pfam_id: PF08683
name: Microtubule-binding calmodulin-regulated spectrin-associated
short_name: CAMSAP_CKK
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08683
counters:
  proteins: 6495
  matches: 6511
  proteomes: 1366
  taxa: 4439
  structures: 9
  alphafold_models: 1174
  domain_architectures: 57
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR014797
description: This is the C-terminal domain of a family of eumetazoan proteins collectively defined as
  calmodulin-regulated spectrin-associated, or CAMSAP, proteins. CAMSAP proteins carry an N-terminal region
  that includes the CH domain, a central region including a predicted coiled-coil and this C-terminal,
  or CKK, domain - defined as being present in CAMSAP, KIAA1078 and KIAA1543, The C-terminal domain is
  the part of the CAMSAP proteins that binds to microtubules. The domain appears to act by producing inhibition
  of neurite extension, probably by blocking microtubule function. CKK represents a domain that has evolved
  with the metazoa. The structure of a murine hypothetical protein from RIKEN cDNA has shown the domain
  to adopt a mainly beta barrel structure with an associated alpha-helical hairpin.