id: Pfam:PF08694
pfam_id: PF08694
name: Ubiquitin-fold modifier-conjugating enzyme 1
short_name: UFC1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08694
counters:
  proteins: 1967
  matches: 1996
  proteomes: 1503
  taxa: 4915
  structures: 28
  alphafold_models: 1687
  domain_architectures: 35
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR014806
description: Ubiquitin-like (UBL) post-translational modifiers are covalently linked to most, if not all,
  target protein(s) through an enzymatic cascade analogous to ubiquitylation, consisting of E1 (activating),
  E2 (conjugating), and E3 (ligating) enzymes. Ubiquitin-fold modifier 1 (Ufm1) a ubiquitin-like protein
  is activated by a novel E1-like enzyme, Uba5, by forming a high-energy thioester bond. Activated Ufm1
  is then transferred to its cognate E2-like enzyme, Ufc1, in a similar thioester linkage. This family
  represents the E2-like enzyme.