id: Pfam:PF08695
pfam_id: PF08695
name: Cytochrome oxidase complex assembly protein 1
short_name: Coa1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08695
counters:
  proteins: 3587
  matches: 3591
  proteomes: 3174
  taxa: 7878
  structures: 0
  alphafold_models: 2908
  domain_architectures: 44
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR014807
description: Coa1 is an inner mitochondrial membrane protein that associates with Shy1 and is required
  for cytochrome oxidase complex IV assembly. It contains a conserved hydrophobic segment (amino acids
  74-92) with the potential to form a membrane-spanning helix. The N-terminus of Coa1 is rich in positively
  charged amino acids and could form an amphipathic alpha helix, characteristic of a mitochondrial presequence.
  A cleavage site for the mitochondrial processing peptidase is predicted adjacent to the presequence.
  Upon in vitro import into mitochondria, Coa1 is processed to a mature form, indicating that it possesses
  a cleavable presequence [[cite:PUB00053933]]. The eukaryotic cytochrome oxidase complex consists of
  12-13 subunits, with three mitochondrial encoded subunits, Cox1-Cox3, forming the core enzyme. Translation
  of the Cox1 transcript requires the two promoters, Pet309 and Mss51, and the latter has an additional
  role in translational elongation. Coa1 is necessary for linking the activity of Mss51 to Cox1 insertion
  into the assembly complex [[cite:PUB00053932]].