id: Pfam:PF08699
pfam_id: PF08699
name: Argonaute linker 1 domain
short_name: ArgoL1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08699
counters:
  proteins: 21447
  matches: 21522
  proteomes: 3107
  taxa: 8566
  structures: 74
  alphafold_models: 18036
  domain_architectures: 419
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR014811
description: ArgoL1 is a region found in argonaute [[cite:PUB00035384]] proteins. It normally co-occurs
  with [pfam:PF02179] and [pfam:PF02171]. It is a linker region between the N-terminal and the PAZ domains.
  It contains an alpha-helix packed against a three-stranded antiparallel beta-sheet with two long beta-strands
  (beta8 and beta9) of the sheet spanning one face of the adjacent N and PAZ domains. L1 together with
  linker 2, L2, PAZ and ArgoN forms a compact global fold [[cite:PUB00038652]].