id: Pfam:PF08768
pfam_id: PF08768
name: THAP4-like, heme-binding beta-barrel domain
short_name: THAP4_heme-bd
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08768
counters:
  proteins: 7499
  matches: 7560
  proteomes: 5589
  taxa: 9588
  structures: 16
  alphafold_models: 5205
  domain_architectures: 73
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR014878
description: This domain can be found in THAP4 from mammals and At1g79260 from Arabidopsis. THAP4 catalyzes
  the heme-based conversion of peroxynitrite into nitrate-NO3- in vitro [[cite:PUB00095798]]. At1g79260
  is a nitrophorin-like heme-binding protein that may reversibly bind nitric oxide (NO) and be involved
  in NO transport [[cite:PUB00063678]]. This entry also includes the beta-barrel domain of Caenorhabditis
  elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and
  sensory ray morphology [[cite:PUB00095799]]. Nitrobindins (Nbs), constituting a heme-protein family
  spanning from bacteria to Homo sapiens, display an all-beta-barrel structural organisation. Proteins
  containing this domain are putatively related to fatty acid-binding proteins (FABPs) [[cite:PUB00040845]].