id: Pfam:PF08843
pfam_id: PF08843
name: Nucleotidyl transferase AbiEii toxin, Type IV TA system
short_name: AbiEii
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08843
counters:
  proteins: 11071
  matches: 11148
  proteomes: 6740
  taxa: 10976
  structures: 19
  alphafold_models: 7331
  domain_architectures: 35
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR014942
description: This family was recently identified as belonging to the nucleotidyltransferase superfamily
  [[cite:PUB00066751]]. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial
  abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi
  system is activated upon infection with phage to abort the cell thus preventing the spread of phage
  through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded
  lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the
  plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread
  in bacteria and archaea. The cognate antitoxin is [pfam:PF13338] [[cite:PUB00075538]].