id: Pfam:PF08845
pfam_id: PF08845
name: Toxin SymE, type I toxin-antitoxin system
short_name: SymE_toxin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08845
counters:
  proteins: 2175
  matches: 2175
  proteomes: 892
  taxa: 1422
  structures: 0
  alphafold_models: 1246
  domain_architectures: 7
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR014944
description: SymE (SOS-induced yjiW gene with similarity to MazE ) is an SOS-induced toxin. It inhibits
  cell growth, decreases protein synthesis and increases RNA degradation. It may play a role in the recycling
  of RNAs damaged under SOS response-inducing conditions. It is predicted to have an AbrB fold, similar
  to that of the antitoxin MazE. Its translation is repressed by the antisense RNA SymR, which acts as
  an antitoxin [[cite:PUB00064452],[cite:PUB00053151]].